Calretinin monoclonal antibody

Product Specifications

Background

Calretinin (29 kDa calbindin, calbindin 2) is a calcium-binding protein of the EF-hand family encoded by the CALB2 gene. It is differentially expressed from homologous family member calbindin-d28k in distinct neuronal populations of the retina, auditory system, and cerebellar granule cells, and acts as a marker for specific neuronal subsets of the subthalamic nucleus and the substantia nigra. Calretinin has been shown to play an important role in modulating neuronal excitability and the induction of long-term potentiation. Research has shown that, pathologically, Calretinin is a selective marker for epithelial mesothelioma, making it a diagnostic tool to differentiate from adenocarcinomas.

CAS Number

9007-83-4

Structure Composition

Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Product Name Alternative

CAB29; Calretinin; CR; 29 kDa calbindin

Swiss Prot

P22676

Reactivity

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within human Calretinin. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

IHC

Dilution

IHC (1/100 - 1/300)

Purity

The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .