Thyroglobulin monoclonal antibody
Product Specifications
Background
Thyroglobulin is a large preprotein containing multiple glycosylation sites. Located in the thyroid gland, Thyroglobulin is the precursor of the iodinated thyroid hormones Thyroxine and Triiodothyronine. Thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulum, prior to forming dimers. This dimerization, as well as export of Thyroglobulin to the Golgi complex, has been shown to require Ca2+. Defects in Thyroglobulin are known to cause some types of goiter (an enlargement of the thyroid gland) . This condition is thought to result from defective dimerization and transport of Thyroglobulin to the Golgi complex.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Product Name Alternative
Thyroglobulin; Tg
Swiss Prot
P01266
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within human Thyroglobulin. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
IHC
Dilution
IHC (1/100 - 1/300)
Purity
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 304 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Thyroglobulin protein.
Host or Source
Mouse
Available Sizes
Curated Selection
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