Cytokeratin 20 monoclonal antibody

Product Specifications

Background

Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments. Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as research biomarkers. Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases. Keratin 20 is primarily expressed in gastric and intestinal epithelium, urothelium, and Merkel cells. Research studies have shown that keratin 20 is an important marker of colon, liver, pancreatic, Merkel cell, and gastric cancer.

CAS Number

9007-83-4

Structure Composition

Mouse IgG2a. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Product Name Alternative

Keratin type I cytoskeletal 20; Cytokeratin-20; CK-20; Keratin-20; K20; Protein IT

Swiss Prot

P35900

Reactivity

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within human Cytokeratin 20. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

IHC

Dilution

IHC (1/100 - 1/300)

Purity

The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .