Fumarase monoclonal antibody
Product Specifications
Background
Fumarate hydratase (Fumarase, FH) is canonically regarded as a mitochondrial enzyme of the tricarboxylic acid cycle that catalyzes fumarate to malate. Studies have demonstrated that deficiencies in FH can lead to hereditary leiomyomatosis and renal cell cancer or, in homozygous germline mutations, severe neurological and muscular disorders. There also exists a cytosolic fumarase isoenzyme that is involved in DNA damage repair.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Fumarate hydratase mitochondrial; Fumarase
Swiss Prot
P07954
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence of human Fumarase. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB, IF/ICC
Dilution
WB (1/1000 - 1/3000), IF/ICC (1/100 - 1/200)
Purity
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 50 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Fumarase protein.
Applications Notes
Western blot analysis of Fumarase expression in 293T (A), HepG2 (B), Hela (C), mouse brain (D), rat brain (E) whole cell lysates.
Host or Source
Mouse
Available Sizes
Frequently Asked Questions
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