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Aquaporin 4 monoclonal antibody

Product Specifications

Background

Forms a water-specific channel (PubMed:7559426, PubMed:8601457, PubMed:19383790) . Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity) .

CAS Number

9007-83-4

Structure Composition

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4

Swiss Prot

P55087

Reactivity

Human, Mouse, Rat

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence of human Aquaporin 4. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

WB, IHC, IF/ICC

Dilution

WB (1/1000 - 1/3000), IHC (1/100 - 1/200), IF/ICC (1/100 - 1/200)

Purity

The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 46 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of Aquaporin 4 protein.

Applications Notes

Western blot analysis of Aquaporin 4 expression in Hela (A), mouse heart (B), rat heart (C) whole cell lysates.

Host or Source

Mouse

Available Sizes

Frequently Asked Questions

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