FOXO4 (phospho-S262) polyclonal antibody
Product Specifications
Background
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
AFX; AFX1; MLLT7; Forkhead box protein O4; Fork head domain transcription factor AFX1
Swiss Prot
P98177
Reactivity
Human, Rat, Mouse
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human FOXO4 with a phosphorylation site at S262. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB, IHC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 157% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 70 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of FOXO4 with a phosphorylation site at S262 protein.
Applications Notes
Western blot analysis of FOXO4 (pS262) expression in mouse muscle (A), rat brain (B), rat muscle (C) whole cell lysates.
Host or Source
Rabbit
Available Sizes
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