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KIF2C (phospho-S95) polyclonal antibody

Product Specifications

Background

In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309) .Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894) .Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108) .

CAS Number

9007-83-4

Structure Composition

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

KNSL6; Kinesin-like protein KIF2C; Kinesin-like protein 6; Mitotic centromere-associated kinesin; MCAK

Swiss Prot

Q99661

Reactivity

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human KIF2C. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

WB, IF/ICC

Dilution

WB (1/500 - 1/1000), IF/IC (1/100 - 1/500)

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Phosphorylation

Molecular Weight

~ 90 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of KIF2C (pS95) protein.

Applications Notes

Western blot analysis of KIF2C (pS95) expression in H1688 (A), H446 (B) whole cell lysates.

Host or Source

Rabbit

Available Sizes

Frequently Asked Questions

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