YAP1 (phospho-S127) polyclonal antibody
Product Specifications
Background
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097) .
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
YAP65; Yorkie homolog; 65 kDa Yes-associated protein; YAP65
Swiss Prot
P46937
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human YAP1 (pS127) . The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
Hippo Signaling
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 73 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of YAP1 (pS127) protein.
Applications Notes
Western blot analysis of YAP1 (pS127) expression in H1688 (A) whole cell lysates.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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