COX7A2/3 polyclonal antibody
Product Specifications
Background
Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
COX7A2P2; COX7A3; COX7AL2; COX7AP2; Putative cytochrome c oxidase subunit 7A3 mitochondrial; Cytochrome c oxidase subunit VIIa 3; COX7A2; COX7AL; Cytochrome c oxidase subunit 7A2 mitochondrial; Cytochrome c oxidase subunit VIIa-liver/heart; Cytochrome c oxidase subunit VIIa-L; Cytochrome c oxidase subunit VIIaL
Swiss Prot
O60397; P14406
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human COX7A2/3. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB, IHC
Dilution
WB (1/500 - 1/1000), IH (1/100 - 1/200)
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 12 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of COX7A2/3 protein.
Applications Notes
Western blot analysis of COX7A2/3 expression in HepG2 (A), Jurkat (B) whole cell lysates.
Host or Source
Rabbit
Available Sizes
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