BMP-7 (E173) polyclonal antibody
Product Specifications
Background
Bone morphogenetic proteins (BMPs) were first identified as molecules that can induce ectopic bone and cartilage formation. BMPs belong to the TGF-β superfamily, playing many diverse functions during development. BMPs are synthesized as precursor proteins and then processed by cleavage to release the C-terminal mature BMP. BMPs initiate signaling by binding to a receptor complex containing type I and type II serine/threonine receptor kinases that then phosphorylate Smad (mainly Smad1, 5, and 8), resulting in the translocation of Smad into the nucleus. BMP was also reported to activate MAPK pathways in some systems.BMP7, also known as osteogenic protein-1 (OP-1), is found to be upregulated in some cancer cells, and may play a role in cancer metastasis.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Bone morphogenetic protein 7; BMP-7; Osteogenic protein 1; OP-1; INN: Eptotermin alfa
Swiss Prot
P18075
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human BMP-7.
Conjugation
Unconjugated
Related Pathways
TGFβ Smad signaling
Applications
WB
Dilution
WB: 1:1000~1:2000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 52 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
BMP-7 (E173) polyclonal antibody detects endogenous levels of BMP-7 protein.
Applications Notes
Western blot (WB) analysis of BMP-7 (E173) ) polyclonal antibody at 1:1000 dilution Lane1:CT26 whole cell lysate (30ug) Lane2:PC12 whole cell lysate (30ug) Lane3:Jurkat whole cell lysate (30ug) Lane4:Hela whole cell lysate (30ug)
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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