CD155 polyclonal antibody

Product Specifications

Background

Poliovirus receptor (PVR, CD155) is an immunoglobulin-like, transmembrane glycoprotein originally described as a mediator of poliovirus attachment to cells and later identified as important in adherens junction formation. Also known as nectin-like 5 (Necl-5), PVR binds nectin-3 and interacts with integrin αvβ3 and PDGFR to regulate integrin clustering and focal contact formation at the leading edge of migrating cells. Research studies demonstrate that PVR and nectin-3 regulate contact inhibition during cell motility and proliferation in transformed 3T3 cells. Additional research indicates that PVR (CD155, Necl-5) expression may play a role in invasiveness of lung adenocarcinoma. In the immune system, CD155 plays a role in natural killer (NK) cell-mediated cytotoxicity.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Product Name Alternative

Poliovirus receptor; Nectin-like protein 5 (NECL-5) ; CD155; PVR; PVS

Swiss Prot

P15151

Reactivity

Human, Mouse

Immunogen

Synthetic peptide, corresponding to Human CD155.

Conjugation

Unconjugated

Applications

Dilution

WB: 1:5000~1:10000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 70 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

CD155 polyclonal antibody detects endogenous levels of CD155 protein.

Applications Notes

Western blot (WB) analysis of CD155 polyclonal antibody at 1:10000 dilution Lane1:CT-26 whole cell lysate (30ug) Lane2:HepG2 whole cell lysate (10ug) Lane3:A549 whole cell lysate (10ug)