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CBX8 monoclonal antibody

Product Specifications

Background

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

CAS Number

9007-83-4

Structure Composition

Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

PC3; RC1; Chromobox protein homolog 8; Polycomb 3 homolog; Pc3; hPc3; Rectachrome 1

Swiss Prot

Q9HC52

Reactivity

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CBX8. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

WB, FC

Dilution

WB (1/500 - 1/1000), FC (1/10 - 1/50)

Purity

This antibody is purified through a protein G column.

Modification

Unmodification

Molecular Weight

~ 50 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of CBX8 protein.

Applications Notes

Western blot analysis of CBX8 expression in 293 (A), Hela (B), A549 (C) whole cell lysates.

Host or Source

Mouse

Available Sizes

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