RAB1B monoclonal antibody
Product Specifications
Background
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity) . Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity) .
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Ras-related protein Rab-1B
Swiss Prot
Q9H0U4
Reactivity
Human
Immunogen
Recombinant fusion protein of human RAB1B. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB, FC
Dilution
WB (1/500 - 1/2000), FC (1/10 - 1/50)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 26 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of RAB1B protein.
Applications Notes
Western blot analysis of RAB1B expression in Hela (A), A431 (B), U20S (C) whole cell lysates.
Host or Source
Mouse
CAS Number
9007-83-4
Available Sizes
Curated Selection
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