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Makorin-2 monoclonal antibody

Product Specifications

Background

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity) . Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity) . Plays a role in the regulation of spermiation and in male fertility (By similarity) .

CAS Number

9007-83-4

Structure Composition

Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

RNF62; Probable E3 ubiquitin-protein ligase makorin-2; RING finger protein 62

Swiss Prot

Q9H000

Reactivity

Human

Immunogen

Recombinant fusion protein of human Makorin-2. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

WB, IHC, IF/ICC, FC

Dilution

WB (1/500 - 1/2000), IHC (1/50 - 1/200), IF/ICC (1/10 - 1/50), FC (1/10 - 1/50)

Purity

This antibody is purified through a protein G column.

Modification

Unmodification

Molecular Weight

~ 50 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of Makorin-2 protein.

Applications Notes

Western blot analysis of Makorin-2 expression in Jurkat (A), K562 (B) whole cell lysates.

Host or Source

Mouse

Available Sizes

Curated Selection

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