VRK1 monoclonal antibody
Product Specifications
Background
The vaccinia-related kinase (VRK) proteins are a new group of Ser/Thr kinases in the human kinome. This mammalian kinase family comprises three members, VRK1, VRK2, and VRK3. The VRK1 has autophosphorylation activity and phosphorylates several transcription factors, including p53, ATF2, and c-Jun. VRK2 is associated with the endoplasmic reticulum. VRK3 suppresses Erk activity through direct interaction and activation of the MAP kinase phosphatase VHR. Further functional and structural analysis of VRK proteins will elucidate important new aspects of cell regulation.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.
Product Name Alternative
Serine/threonine-protein kinase VRK1; Vaccinia-related kinase 1
Swiss Prot
Q99986
Reactivity
Human
Immunogen
Recombinant fusion protein of human VRK1. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/2000)
Modification
Unmodification
Molecular Weight
~ 48 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of VRK1 protein.
Applications Notes
Western blot analysis of VRK1 expression in Hela (A), HL60 (B) whole cell lysates.
Host or Source
Mouse
Available Sizes
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