TSC1 monoclonal antibody
Product Specifications
Background
Atg4A predominately cleaves GATE-16, athough it can cleave the other mammalian Atg8 homologues with lesser efficiencies. Mutation in the corresponding Atg4A gene is critical for redox regulation and inhibits autophagosome formation. Expression of this Atg4A mutation demonstrates a role for reactive oxygen species in nutrient-deprived autophagy.
CAS Number
9007-83-4
Structure Composition
Mouse IgG2b. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
KIAA0243; TSC; Hamartin; Tuberous sclerosis 1 protein
Swiss Prot
Q92574
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human TSC1. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
AMPK Signaling Pathway, MTOR signaling
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 160 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of TSC1 protein.
Applications Notes
Western blot analysis of TSC1 expression in mouse brain (A) whole cell lysates.
Host or Source
Mouse
Available Sizes
Frequently Asked Questions
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