HACE1 monoclonal antibody
Product Specifications
Background
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
KIAA1320; E3 ubiquitin-protein ligase HACE1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1
Swiss Prot
Q8IYU2
Reactivity
Human
Immunogen
Recombinant fusion protein of human HACE1. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 95 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of HACE1 protein.
Applications Notes
Western blot analysis of HACE1 expression in 293 (A), 293T (B) whole cell lysates.
Host or Source
Mouse
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
RC210291 10 µg
Myelin Basic Protein (MBP) (NM_001025092) Human Tagged ORF Clone
Sign In for Pricing
View Details 
129235-ML490 100 µL
LSD1 (Lysine-specific Histone Demethylase 1A, BRAF35-HDAC Complex Protein BHC110, Flavin-containing Amine Oxidase Domain-containing Protein 2, KDM1A, AOF2, KDM1, KIAA0601) (MaxLight 490)
Sign In for Pricing
View Details 
abx449289 100 µg
Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) Antibody (Streptavidin)
Sign In for Pricing
View Details 