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GLK monoclonal antibody

Product Specifications

Background

The mTORC1 kinase complex is a critical regulator of cell growth. Its activity is modulated by growth factors and nutrients including amino acids. MAP4K3 is a mediator between nutrient signal and mTORC1. Research studies suggest that amino acid sufficiency leads to the phosphorylation of Ser170 on MAP4K3, which activates mTORC1 .

CAS Number

9007-83-4

Structure Composition

Mouse IgM kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

RAB8IPL1; Mitogen-activated protein kinase kinase kinase kinase 3; Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3

Swiss Prot

Q8IVH8

Reactivity

Human

Immunogen

Recombinant fusion protein of human GLK. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

WB, IHC

Dilution

WB (1/500 - 1/1000), IHC (1/50 - 1/100)

Purity

This antibody is purified through a protein G column.

Modification

Unmodification

Molecular Weight

~ 105 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of GLK protein.

Applications Notes

Western blot analysis of GLK expression in MCF7 (A) whole cell lysates.

Host or Source

Mouse

Available Sizes

Frequently Asked Questions

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