IHH monoclonal antibody
Product Specifications
Background
Indian hedgehog (Ihh) is a cell signaling protein that is one of the three proteins in the hedgehog family. Ihh is expressed in adult kidney and liver and acts as an antagonist of the Wnt signaling pathway in colon cancers. The Wnt signaling pathway plays a role in carcinogenesis and in embryonic development, and any gene mutations in this pathway lead to various diseases. The Ihh protein is involved in chondrocyte differentiation, proliferation, and maturation especially during endochondral ossification, and is a regulator of bone growth.
CAS Number
9007-83-4
Structure Composition
Mouse IgG3. Supplied in crude ascites with 0.01% sodium azide.
Product Name Alternative
Indian hedgehog protein; IHH; HHG-2
Swiss Prot
Q14623
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human IHH. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/4000)
Modification
Unmodification
Molecular Weight
~ 45 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of IHH protein.
Applications Notes
Western blot analysis of IHH expression in CEM (A) whole cell lysates.
Host or Source
Mouse
Available Sizes
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