VILIP-1 monoclonal antibody

Visinin-like Protein 1, also called VILIP-1 and VSNL1, is a calcium-sensing protein in the central nervous system. Visinin-like Protein 1 exhibits a widespread distribution with high expression in the CNS, and lower expression levels in some peripheral tissues . Visinin-like Protein 1 responds to increased intracellular calcium concentration by translocating from the cytoplasm to membranes through calcium-dependent myristoylation at its N-terminus that allows interaction with membranes . This change in localization has been proposed to facilitate the activation of compartment-specific signal transduction for the selective activation of downstream signaling cascades . In Alzheimer’s disease, Visinin-like Protein 1 expression is decreased in the brain, including a reduced number of Visinin-like Protein 1 immunoreactive neurons ; however, the presence of the protein is increased in the CSF , suggesting that it is released from neurons during insults.