RAB8A monoclonal antibody

The Rab8 GTPase is a member of the Ras superfamily that functions in protein transport and membrane restructuring . Studies show that Rab8 is localized to the trans Golgi network (TGN), basolateral membrane, and vesicular structures where it helps regulate target protein transport between TGN and the basolateral membrane . Overexpression studies and mutation analysis of Rab8 and its associated Rab8GEF indicate additional roles in actin and microtubule remodeling during polarized membrane transport and membrane protrusion formation . Rab8 associates with myosin Vb and is required for translocation of GLUT4 following insulin stimulation in muscle . Control of target protein vesicle transport by Rab8 also regulates MT1-MMP activity during extracellular matrix formation and JRAB/MICAL-L2 at tight junction formation .