RAB8A monoclonal antibody
Product Specifications
Background
The Rab8 GTPase is a member of the Ras superfamily that functions in protein transport and membrane restructuring . Studies show that Rab8 is localized to the trans Golgi network (TGN), basolateral membrane, and vesicular structures where it helps regulate target protein transport between TGN and the basolateral membrane . Overexpression studies and mutation analysis of Rab8 and its associated Rab8GEF indicate additional roles in actin and microtubule remodeling during polarized membrane transport and membrane protrusion formation . Rab8 associates with myosin Vb and is required for translocation of GLUT4 following insulin stimulation in muscle . Control of target protein vesicle transport by Rab8 also regulates MT1-MMP activity during extracellular matrix formation and JRAB/MICAL-L2 at tight junction formation .
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
MEL; RAB8; Ras-related protein Rab-8A; Oncogene c-mel
Swiss Prot
P61006
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human RAB8A. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 23 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of RAB8A protein.
Applications Notes
Western blot analysis of RAB8A expression in Hela (A), HCT116 (B) whole cell lysates.
Host or Source
Mouse
Available Sizes
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