IL-2 monoclonal antibody
Product Specifications
Background
Interleukin-2 (IL-2) is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation . IL-2 also promotes peripheral development of regulatory T cells (Tregs) . Conversely, IL-2 is involved in the activation-induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells . The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Rα, IL-2Rβ, and the common gamma chain, γc . IL-2Rα binds exclusively to IL-2 with low affinity and increases the binding affinity of the whole receptor complex including IL-2Rβ and γc subunits. IL-15 also binds to IL-2Rβ . γc is used by other cytokines, including IL-4, IL-7, IL-9, IL-15, and IL-21 . Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5, and the PI3K/Akt pathways .
CAS Number
9007-83-4
Structure Composition
Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.
Product Name Alternative
Interleukin-2; IL-2; T-cell growth factor; TCGF; Aldesleukin
Swiss Prot
P60568
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-2. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Modification
Unmodification
Molecular Weight
~ 17 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of IL-2 protein.
Applications Notes
Western blot analysis of IL-2 expression in K562 (A) whole cell lysates.
Host or Source
Mouse
Available Sizes
Curated Selection
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