PTEN monoclonal antibody

Product Specifications

Background

PTEN (phosphatase and tensin homologue deleted on chromosome ten), also referred to as MMAC (mutated in multiple advanced cancers) phosphatase, is a tumor suppressor implicated in a wide variety of human cancers . PTEN encodes a 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase . The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3-kinase (PI3K) . PTEN is a major negative regulator of the PI3K/Akt signaling pathway . PTEN possesses a carboxy-terminal, noncatalytic regulatory domain with three phosphorylation sites (Ser380, Thr382, and Thr383) that regulate PTEN stability and may affect its biological activity . PTEN regulates p53 protein levels and activity and is involved in G protein-coupled signaling during chemotaxis .

CAS Number

9007-83-4

Structure Composition

Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

MMAC1; TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog

Swiss Prot

P60484

Reactivity

Human, Mouse, Rat

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PTEN. The exact sequence is proprietary.

Conjugation

Unconjugated

Related Pathways

Inhibition of Apoptosis, Regulation of Microtubule Dynamics, PI3K AKT signaling, Translational Contral elF4 and p70 S6 Kinase, MTOR signaling.

Applications

Dilution

WB (1/500 - 1/1000)

Purity

This antibody is purified through a protein G column.

Modification

Unmodification

Molecular Weight

~ 54 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of PTEN protein.

Applications Notes

Western blot analysis of PTEN expression in Hela (A), C6 (B), NIH3T3 (C) whole cell lysates.

Host or Source

Mouse

Available Sizes

Curated Selection

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