PLP1 monoclonal antibody
Product Specifications
Background
Myelin proteolipid protein (PLP1) corresponds to the majority of myelin proteins in the CNS, providing support to axons and modulating the axonal growth . DM20 is the result of the alternative splicing of the plp1 gene, which is linked to oligodendrocyte differentiation and survival. The imbalance of PLP1/DM20 is linked to Pelizaeus-Merzbacher disease , including mitochondrial damage . In addition, PLP1, but not DM20, can enter the mitochondria and participate in the metabolism of cells .
CAS Number
9007-83-4
Structure Composition
Mouse IgM. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
PLP; Myelin proteolipid protein; PLP; Lipophilin
Swiss Prot
P60201
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PLP1. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 34 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of PLP1 protein.
Applications Notes
Western blot analysis of PLP1 expression in C6 (A), Hela (B), mouse cerebellum (C) whole cell lysates.
Host or Source
Mouse
Available Sizes
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