Hexokinase 2 monoclonal antibody
Product Specifications
Background
Hexokinase catalyzes the conversion of glucose to glucose-6-phosphate, the first step in glycolysis. Four distinct mammalian hexokinase isoforms, designated as hexokinase I, II, III, and IV (glucokinase), have been identified. Hexokinases I, II, and III are associated with the outer mitochondrial membrane and are critical for maintaining an elevated rate of aerobic glycolysis in cancer cells (Warburg Effect) in order to compensate for the increased energy demands associated with rapid cell growth and proliferation .
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Hexokinase-2; Hexokinase type II; HK II; Muscle form hexokinase
Swiss Prot
P52789
Reactivity
Human
Immunogen
Recombinant fusion protein of human Hexokinase 2. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
Warburg Effect.
Applications
WB
Dilution
WB (1/1000 - 1/2000), IHC (1/50 - 1/200)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 105 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Hexokinase 2 protein.
Applications Notes
Western blot analysis of Hexokinase 2 expression in Hela (A), 293 (B), Jurkat (C) whole cell lysates.
Host or Source
Mouse
Available Sizes
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