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YY1 monoclonal antibody

Product Specifications

Background

YY1 is a ubiquitously expressed transcription factor with fundamental roles in embryogenesis, differentiation, replication and proliferation. YY1 contains four zinc finger motifs of the Cys-Cys-His-His type and can activate different eukaryotic genes or repress different eukaryotic genes as well as regulate some viral promoters . YY1 deficient embryos die approximately at the time of implantation, suggesting that YY1 has an essential role in embryonic development. YY1 is overexpressed in cancer cells such as prostate cancer and therefore may be considered a prognostic marker .

CAS Number

9007-83-4

Structure Composition

Mouse IgG2a . Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

INO80S; Transcriptional repressor protein YY1; Delta transcription factor; INO80 complex subunit S; NF-E1; Yin and yang 1; YY-1

Swiss Prot

P25490

Reactivity

Human, Rat, Monkey, Zebrafish

Immunogen

Recombinant fusion protein of human YY1. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

WB, IHC

Dilution

WB (1/1000 - 1/2000), IHC (1/50 - 1/200)

Purity

This antibody is purified through a protein G column.

Modification

Unmodification

Molecular Weight

~ 65 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of YY1 protein.

Applications Notes

Western blot analysis of YY1 expression in 293 (A), C6 (B), Hela (C), U251 MG (D) whole cell lysates.

Host or Source

Mouse

Available Sizes

Frequently Asked Questions

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