FR beta monoclonal antibody

Product Specifications

Background

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

CAS Number

9007-83-4

Structure Composition

Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

Folate receptor beta; FR-beta; Folate receptor 2; Folate receptor, fetal/placental; Placental folate-binding protein; FBP

Swiss Prot

P14207

Reactivity

Human

Immunogen

Recombinant fusion protein of human FR beta. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

Dilution

WB (1/500 - 1/1000)

Purity

This antibody is purified through a protein G column.

Modification

Unmodification

Molecular Weight

~ 30 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of FR beta protein.

Applications Notes

Western blot analysis of FR beta expression in human spleen (A), human placenta (B) whole cell lysates.

Host or Source

Mouse

Available Sizes

Curated Selection

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