CD20 monoclonal antibody
Product Specifications
Background
B-lymphocyte antigen CD20 is a cell surface phosphoprotein involved in the regulation of B cell activation and proliferation . It is commonly used as a marker to identify B cells and is expressed throughout B cell development, up until their differentiation into plasma cells. CD20 has no known ligand, and its expression and function are largely conserved between human and mouse . Evidence suggests that CD20 is necessary for store operated calcium entry, which leads to elevated cytoplasmic calcium levels required for B cell activation . Anti-CD20 antibody immunotherapy depletes B cells by activation of the innate monocytic network and is a common treatment for B cell lymphomas, leukemias, and autoimmune diseases .
CAS Number
9007-83-4
Structure Composition
Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
CD20; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD20
Swiss Prot
P11836
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD20. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB, IHC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 35 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of CD20 protein.
Applications Notes
Western blot analysis of CD20 expression in Ramos (A) whole cell lysates.
Host or Source
Mouse
Available Sizes
Curated Selection
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