CD20 monoclonal antibody

B-lymphocyte antigen CD20 is a cell surface phosphoprotein involved in the regulation of B cell activation and proliferation . It is commonly used as a marker to identify B cells and is expressed throughout B cell development, up until their differentiation into plasma cells. CD20 has no known ligand, and its expression and function are largely conserved between human and mouse . Evidence suggests that CD20 is necessary for store operated calcium entry, which leads to elevated cytoplasmic calcium levels required for B cell activation . Anti-CD20 antibody immunotherapy depletes B cells by activation of the innate monocytic network and is a common treatment for B cell lymphomas, leukemias, and autoimmune diseases .

CD20; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD20