Cytochrome P450 2C9 monoclonal antibody

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase.Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids.Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis .Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 .Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids .Also metabolizes plant monoterpenes such as limonene. Oxygenates (R) - and (S) -limonene to produce carveol and perillyl alcohol .Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan .

CYP2C10; Cytochrome P450 2C9; (R) -limonene 6-monooxygenase; (S) -limonene 6-monooxygenase; (S) -limonene 7-monooxygenase; CYPIIC9; Cytochrome P-450MP; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; S-mephenytoin 4-hydroxylase