P53 monoclonal antibody

P53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosisrelated genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.

AMPK Signaling Pathway, Regulation of Apoptosis, ErbB HER Signaling, Cell Cycle Control G1 S Checkpoin, Cell Cycle G2 M DNA Damage Signaling Pathway, MTOR signalingNecrotic Cell DeathNeuronal and Glial Cell Marker AtlasNF-kB SignalingNotch SignalingNuclear Receptor SignalingPhosphoinosotode SignalingPhospholipase SignalingPI3K AKT signalingProtein Kinase C SignalingRegulation of Actin DynamicsRegulation of ApoptosisRegulation of Microtubule DynamicsSAPK JNK Signaling CascadesSignaling Pathways Activating p38 MAP KinaseSTING SignalingT cell receptor signalingTGFβ Smad signalingToll-like Receptor signalingTranslational Contral elF4 and p70 S6 KinaseTranslational Contral Regulation of elF2Tumor AngiogenesisTumor-Infiltrating Immune Cell Marker GuideUbiquitin ProteasomeVesicle Trafficking presynaptic signalingWarburg EffectWntβ catenin signaling, PI3K AKT signaling, SAPK JNK Signaling Cascades, Warburg Effect