APCS monoclonal antibody
Product Specifications
Background
Serum amyloid P (SAP) is a glycoprotein belonging to the pentraxin family of proteins, which has a characteristic pentameric organization and calciumdependent ligand binding. Secreted by liver epithelial cells, SAP is found in serum and urine. Although the function of SAP has not been clearly established, it has been shown to interact with DNA and histones and is thought to play a role in scavenging nuclear material released from damaged circulating cells. Also designated PTX2, SAP is a precursor of the protein amyloid P component (AP), which is universally associated with the amyloid deposits in all forms of amyloidoses, including Alzheimer’s disease. SAP is a decamer of ten identical, noncovalently linked subunits, each of which may be posttranslationally modified by glycosylation.
CAS Number
9007-83-4
Structure Composition
Mouse IgG2a. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
PTX2; Serum amyloid P-component; SAP; 9.5S alpha-1-glycoprotein
Swiss Prot
P02743
Reactivity
Human
Immunogen
Recombinant fusion protein of human APCS. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 28 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of APCS protein.
Applications Notes
Western blot analysis of APCS expression in NCIH460 (A) whole cell lysates.
Host or Source
Mouse
Available Sizes
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