IGHD monoclonal antibody
Product Specifications
Background
IgD chain C (Ig d chain C region) is an allelic product of the human IGHD gene. The two known IGHD alleles, IGHD*01 and IGHD*02, respectively produce isoforms 1, a secreted protein, and 2, a single-pass type I membrane protein. A member of the adaptive immune system, IgD antibodies are monomers expressed by activated B cells. Containing three Ig-like (immunoglobulin-like) domains, IgD chain C is located on chromosome 14 within the human heavy chain locus, lying on the 3' side of the IgM chain C region from the V-D-J cassette. Polyadenylation at certain sites along the heavy chain locus likely effects the mechanism that determines the alternative splicing event which results in the expression of either IgD chain C or IgM chain C. Some studies have suggested that antigenic coactivation of IgD+ B cells can have a negative influence on bone resorption during infectious events.
CAS Number
9007-83-4
Structure Composition
Mouse IgM. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Ig delta chain C region
Swiss Prot
P01880
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IGHD. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/100 - 1/500)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 57 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of IGHD protein.
Applications Notes
Western blot analysis of IGHD expression in CEM (A) whole cell lysates.
Host or Source
Mouse
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
