IFN alpha 1 monoclonal antibody
Product Specifications
Background
The genes encoding type I interferons (IFNs), which include 14 IFN-a genes, one IFN-β gene, one IFN-w (also known as IFN-a II1) gene, and a number of IFN-w pseudogenes, are clustered on human chromosome 9. Interferon-a and -β are cytokines that are widely known to induce potent antiviral activity. They exert a variety of other biological effects, including antitumor and immunomodulatory activities and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases. IFN-w is antigenically different from human IFN-a, IFN-β or IFN-g, but is a component of natural mixtures of IFN species produced by virus-induced leukocytes or Burkitt’s lymphoma cells. The type I interferon receptor (IFN-aR) interacts with IFN-a, IFN-β and IFN-w, and seems to be a multisubunit receptor.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Interferon alpha-1/13; IFN-alpha-1/13; Interferon alpha-D; LeIF D
Swiss Prot
P01562
Reactivity
Human
Immunogen
Recombinant fusion protein of human IFN alpha 1. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 17 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of IFN alpha 1 protein.
Applications Notes
Western blot analysis of IFN alpha 1 expression in IFN (A) whole cell lysates.
Host or Source
Mouse
Available Sizes
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