PENK monoclonal antibody
Product Specifications
Background
The corticotropin-lipotropin protein, also designated pro-opiomelanocortin, belongs to the POMC family of proteins. Specific cleavages by enzymes at certain basic paired residues yield various processed active peptides. The corticotropin-lipotropin protein contains synenkephalin, Leu-enkephalin, NPP, a-, b- and g-melanotropin (MSH), adrenocorticotropic hormone (ACTH), lipotropin b and g, b-endorphin and Met-enkephalin processed active peptides.b-endorphin and Met-enkephalin are endogenous opiates while ACTH is crucial for adrenal gland stimulation to release cortisol. Met/Leu-enkephalins also function in pain perception and response to stress. MSH increased melanin production in melanocytes which leads to an increase in skin pigmentation. Leumorphin may be important in apoptosis prevention by being involved in the MAP-K and PI3-K pathways.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Proenkephalin-A
Swiss Prot
P01210
Reactivity
Human
Immunogen
Recombinant fusion protein of human PENK. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 34 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of PENK protein.
Applications Notes
Western blot analysis of PENK expression in T47D (A) whole cell lysates.
Host or Source
Mouse
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
