Adenosine Deaminase monoclonal antibody
Product Specifications
Background
Adenosine deaminase is an enzyme that is present in most tissues. It exists predominantly as a monomer, although in some tissues it is associated with adenosine deaminase-binding protein. Adenosine deaminase degrades extracellular adenosine, which is toxic for lymphocytes. Adenosine deaminase also effects co-stimulatory signals in T cells via interactions with CD26. Deficiency of adenosine deaminase has been shown to lead to immunodeficiency diseases such as SCID (severe combined immunodeficiency disease) and has been associated with hereditary hemolytic anemia, a disease in which adenosine deaminase levels are elevated fifty to seventy fold.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
ADA1; Adenosine deaminase; Adenosine aminohydrolase
Swiss Prot
P00813
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Adenosine Deaminase. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 39 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Adenosine Deaminase protein.
Applications Notes
Western blot analysis of Adenosine Deaminase expression in CEM (A), Jurkat (B) whole cell lysates.
Host or Source
Mouse
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