USP2 monoclonal antibody
Product Specifications
Background
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove Ub, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP2 (Ub specific peptidase 2), also known as 41 kDa Ub-specific protease, is a 605 amino acid deubiquitinating enzyme that participates in the Ub pathway. Localized to the cytoplasm, USP2 forms a homooligomer and catalyzes the reaction of the Ub C-terminal thioester with water to form Ub and a thiol. USP2 is expressed as two isoforms produced by alternative splicing.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
UBP41; Ubiquitin carboxyl-terminal hydrolase 2; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2
Swiss Prot
O75604
Reactivity
Human, Monkey
Immunogen
Recombinant fusion protein of human USP2. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of USP2 protein.
Applications Notes
Western blot analysis of USP2 expression in MCF7 (A), PC3 (B), COS7 (C), Du145 (D), SKBR3 (E) whole cell lysates.
Host or Source
Mouse
Available Sizes
Frequently Asked Questions
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