GMFG monoclonal antibody

GMF-γ (glia maturation factor, γ), also known as GMFG, is a 142 amino acid protein that belongs to the GMF subfamily of the larger Actin-binding protein ADF family. GMF-γ is expressed predominantly in lung, heart and placenta.GMF-γ is considered a candidate regulatory growth factor protein, mediating both paracrine and autocrine cell-cell interactions. GMF-γ is phosphorylated at N-terminal serine, and its phosphorylation is enhanced by coexpression of dominant active Rac 1 and Cdc42. GMF-γ expression is significantly increased in a cardiac ischemia/reperfusion model where inflammation and angiogenesis take place actively. As a regulator of Actin-based cellular functions, GMF-γ may provide a novel approach to modulate the pathophysiology of cardiovascular diseases. GMF-γ is primarily found in proliferative and differentiative organs.