VEGFD monoclonal antibody
Product Specifications
Background
The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis.Several growth factors with angiogenic activity have been described. These include fibroblast growth factor (FGF), platelet derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) . Several forms of VEGF have been identified, including VEGF, VEGF-B, VEGF-C and VEGF-D (also designated FIGF) .Characteristic of VEGF proteins, the central region of VEGF-D contains eight cysteine residues.These residues are essential for homodimerization. VEGF-D may play a role in tumor progression, as it is induced by c-Fos, which is required for conversion of early stage tumors to malignant tumors. It has been observed that overexpression of VEGF-D induces morphological changes in fibroblasts.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
VEGFD; Vascular endothelial growth factor D; VEGF-D; c-Fos-induced growth factor; FIGF
Swiss Prot
O43915
Reactivity
Human, Mouse
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human VEGFD. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 40 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of VEGFD protein.
Applications Notes
Western blot analysis of VEGFD expression in MCF7 (A) whole cell lysates.
Host or Source
Mouse
Available Sizes
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