Lamin A/C monoclonal antibody
Product Specifications
Background
Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization. Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment. The cleavage of lamins results in nuclear dysregulation and cell death.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
LMN1; Prelamin-A/C
Swiss Prot
P02545
Reactivity
Human, Mouse, Rat
Immunogen
Purified recombinant human LMNA protein fragments expressed in E.coli.
Conjugation
Unconjugated
Related Pathways
Death Receptor Signaling, PI3K AKT signaling.
Applications
WB, IF/ICC
Dilution
WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 74, 63 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Lamin A/C protein.
Applications Notes
Western blot analysis of Lamin A/C expression in MCF7 (A), A549 (B), Hela (C) whole cell lysates.
Host or Source
Mouse
Available Sizes
Frequently Asked Questions
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