Lamin A/C monoclonal antibody
Product Specifications
Background
Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization. Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment. The cleavage of lamins results in nuclear dysregulation and cell death.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
LMN1; Prelamin-A/C
Swiss Prot
P02545
Reactivity
Human, Mouse, Rat
Immunogen
Purified recombinant human LMNA protein fragments expressed in E.coli.
Conjugation
Unconjugated
Related Pathways
Death Receptor Signaling, PI3K AKT signaling.
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 74 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Lamin A/C protein.
Applications Notes
Western blot analysis of Lamin A/C expression in K562 (A), C6 (B), NIH3T3 (C), Hela (D) whole cell lysates.
Host or Source
Mouse
Available Sizes
Curated Selection
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