GSK3 beta monoclonal antibody

Product Specifications

Background

Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.

CAS Number

9007-83-4

Structure Composition

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Product Name Alternative

Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B

Swiss Prot

P49841

Reactivity

Human, Mouse, Rat

Immunogen

Purified recombinant GSK-3β protein fragments expressed in E.coli.

Conjugation

Unconjugated

Related Pathways

Adherens Junction signaling, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer\'s Disease, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, Cell Cycle Control G1 S Checkpoin, MAPK Erk in Growth and Differentiation Pathway, Hedgehog Signaling, Inhibition of Apoptosis, Insulin &Glucose Signaling, Regulation of Microtubule Dynamics, NF-kB Signaling, PI3K AKT signaling, Translational Contral Regulation of elF2, Translational Contral elF4 and p70 S6 Kinase, Wntβ catenin signaling, MTOR signaling.