TFIIB monoclonal antibody

Product Specifications

Background

TFIIB (also known as GTF2B, TF2B and general transcription factor IIB) is a ubiquitously expressed transcription factor that plays a central role in the assembly of the transcription pre-initiation complex through direct recruitment of RNA polymerase II. TFIIB functions as a bridge between promoter-bound TFIID and RNA polymerase II. In addition to interacting with promoter-bound TFIID and TFIIA, TFIIB makes extensive contacts with the core promoter via two independent DNA-binding modules. TFIIB may also be a target of transcriptional activator proteins that act to stimulate pre-initiation complex assembly.

CAS Number

9007-83-4

Structure Composition

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Product Name Alternative

TF2B; TFIIB; Transcription initiation factor IIB; General transcription factor TFIIB; S300-II

Swiss Prot

Q00403

Reactivity

Human, Mouse, Monkey

Immunogen

Purified recombinant human TFIIB protein fragments expressed in E.coli.

Conjugation

Unconjugated

Applications

Dilution

WB (1/500 - 1/1000)

Purity

The antibody was purified by immunogen affinity chromatography.

Modification

Unmodification

Molecular Weight

~ 35 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of TFIIB protein.

Applications Notes

Western blot analysis of TFIIB expression in Jurkat (A), MCF7 (B), COS7 (C), NIH3T3 (D), Hela (E) whole cell lysates.

Host or Source

Mouse

Available Sizes

Curated Selection

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