Metadherin monoclonal antibody
Product Specifications
Background
Lyric/AEG-1 (Astrocyte Elevated Gene 1) /MTDH (Metadherin) was identified as a tight junction (TJ) protein based on its localization to TJ proteins in polarized epithelium. Differential subcellular localization and overexpression of Lyric/AEG-1/MTDH has been seen in multiple human cancers. Lyric/AEG-1/MTDH is involved in signaling pathways related to various cellular functions including proliferation and apoptosis/survival, and its alteration in cancer is associated with poor prognosis. In breast cancer, increased Lyric/AEG-1/MTDH may confer increased chemoresistance as well as metastasis. Lyric/AEG-1/MTDH expression is important in signaling and disease progression of hepatocellular carcinoma (HCC) and glioblastoma multiforme (GBM) .
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
AEG1; LYRIC; Protein LYRIC; 3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein
Swiss Prot
Q86UE4
Reactivity
Human
Immunogen
Purified recombinant fragment of human Metadherin expressed in E. Coli.
Conjugation
Unconjugated
Applications
WB, IHC, FC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/100), FC (1/50 - 1/100)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 60 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Metadherin protein.
Applications Notes
Western blot analysis of Metadherin expression in Jurkat (A), A549 (B), MCF7 (C), Hela (D) whole cell lysates.
Host or Source
Mouse
Available Sizes
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