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PYK2 monoclonal antibody

Product Specifications

Background

Protein tyrosine kinase Pyk2, also called CAKβ, RAFTK and CADTK, is a nonreceptor tyrosine kinase structurally related to focal adhesion kinase (FAK) . Pyk2 is predominantly expressed in cells derived from hematopoietic lineages and in the central nervous system. Pyk2 is one of the signaling mediators for the G-protein-coupled receptors and MAP kinase signaling pathway. It plays an important role in cell spreading and migration.

CAS Number

9007-83-4

Structure Composition

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Product Name Alternative

FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Proline-rich tyrosine kinase 2; Related adhesion focal tyrosine kinase; RAFTK

Swiss Prot

Q14289

Reactivity

Human

Immunogen

Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.

Conjugation

Unconjugated

Related Pathways

G-Protein-Coupled Receptors Signaling to MAPK/Erk, MAPK/Erk in Growth and Differentiation.

Applications

WB, IHC

Dilution

WB (1/500 - 1/1000), IHC (1/50 - 1/100)

Purity

The antibody was purified by immunogen affinity chromatography.

Modification

Unmodification

Molecular Weight

~ 116 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of PYK2 protein.

Applications Notes

Western blot analysis of PYK2 expression in A549 (A), Ramos (B), Jurkat (C), THP1 (D), Raji (E) whole cell lysates.

Host or Source

Mouse

Available Sizes

Frequently Asked Questions

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