Lupus La monoclonal antibody
Product Specifications
Background
La antigen is recognized by antibodies in patients with autoimmune disorders such as systemic lupus erythematosus and Sjögren's syndrome. La antigen binds to the 5'-noncoding region of poliovirus RNA and is an IRES trans-acting factor. Depletion of La antigen reduces the function of poliovirus IRES in vivo. La antigen, when phosphorylated at Ser366, has been shown to associate with nuclear precursor tRNAs and facilitate their processing. The nonphosphorylated La antigen interacts with the mRNAs that have 5'-terminal oligopyrimidine (5'TOP) motifs to control protein synthesis.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
Lupus La protein; La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B
Swiss Prot
P05455
Reactivity
Human
Immunogen
Purified recombinant human La Antigen protein fragments expressed in E.coli.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 50 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Lupus La protein.
Applications Notes
Western blot analysis of Lupus La expression in MCF7 (A), A549 (B), Jurkat (C), Hela (D) whole cell lysates.
Host or Source
Mouse
Available Sizes
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