XRCC1 monoclonal antibody
Product Specifications
Background
The X-ray repair cross complementing protein 1 (XRCC1) is a DNA repair protein important in both single strand break repair and base excision repair following damage from ionizing radiation and alkylating agents. XRCC1 acts as a scaffold protein to coordinate DNA abasic site repair through interaction with several other repair proteins. At least eight XRCC1 protein partners have been identified, including the polynucleotide kinase PNK, DNA ligase III, poly (ADP-ribose) polymerase, and PCNA. Mutations and polymorphisms in the XRCC1 gene serve as diagnostic markers and are associated with elevated risk of various forms of cancers.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
DNA repair protein XRCC1; X-ray repair cross-complementing protein 1
Swiss Prot
P18887
Reactivity
Human
Immunogen
Purified recombinant human XRCC1 protein fragments expressed in E.coli.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 82 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of XRCC1 protein.
Applications Notes
Western blot analysis of XRCC1 expression in Raji (A), K562 (B), Hela (C), Jurkat (D), THP1 (E) whole cell lysates.
Host or Source
Mouse
Available Sizes
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