What is the catalog number for TAK1 monoclonal antibody?

The catalog number for TAK1 monoclonal antibody is MB66585.

What sizes are available for TAK1 monoclonal antibody?

TAK1 monoclonal antibody is available in the following size(s): 50 µL, 100 µL.

How many pack sizes does TAK1 monoclonal antibody come in?

TAK1 monoclonal antibody is available in 2 different pack sizes.

Is TAK1 monoclonal antibody in stock?

TAK1 monoclonal antibody is currently made to order / not held in immediate stock. Contact us for lead time.

TAK1 monoclonal antibody

Product Specifications

Background

TAK1 is a mitogen-activated protein kinase kinase kinase that can be activated by TGF-β, bone morphogenetic protein and other cytokines including IL-1. In vivo activation of TAK1 requires association with TAK1 binding protein 1 (TAB1), which triggers phosphorylation of TAK1. Another adaptor protein, TAB2, links TAK1 with TRAF6 and mediates TAK1 activation upon IL-1 stimulation. Once activated, TAK1 phosphorylates MAPK kinases MKK4 and MKK3/6, which activate p38 MAPK and JNK, respectively. In addition, TAK1 activates the NF-κB pathway by interacting with TRAF6 and phosphorylating the NF-κB inducing kinase (NIK) .

CAS Number

9007-83-4

Structure Composition

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Product Name Alternative

TAK1; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1

Swiss Prot

O43318

Reactivity

Human, Mouse, Rat, Monkey

Immunogen

Purified recombinant human TAK1 protein fragments expressed in E.coli.

Conjugation

Unconjugated

Related Pathways

Regulation of Actin Dynamics, Regulation of Apoptosis, G Protein-coupled Receptors Signaling to MAPK Erk, Inhibition of Apoptosis, NF-kB Signaling, SAPK JNK Signaling Cascades, TGFβ Smad signaling, Toll-like Receptor signaling, Wntβ catenin signaling