CBR1 monoclonal antibody
Product Specifications
Background
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol.Can convert prostaglandin E to prostaglandin F2-alpha (By similarity) .Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
CBR; CRN; Carbonyl reductase [NADPH] 1; 15-hydroxyprostaglandin dehydrogenase [NADP (+) ]; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E (2) 9-reductase
Swiss Prot
P16152
Reactivity
Human
Immunogen
Purified recombinant human CBR1 protein fragments expressed in E.coli
Conjugation
Unconjugated
Applications
WB, IF/ICC
Dilution
WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 28 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of CBR1 protein.
Applications Notes
Western blot analysis of CBR1 expression in Hela (A), A431 (B), MDAMB468 (C) whole cell lysates.
Host or Source
Mouse
Available Sizes
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